It is our hope that providing radiation oncologists in-training with a firm foundation underlying the biologic principles of therapeutic radiation will ultimately yield more Lecture 21 Cancer Genetics I Stephen B. Gruber, MD, PhD November 18, 2002 “Cancer is, in essence, a genetic disease. Psychology 2040A/B Lecture Notes - Lecture 15: Homeostasis Lecture Note PSY 001 Lecture Notes - Lecture 20: Facial Feedback Hypothesis, Autonomic Nervous System, Botulinum Toxin Cancer cells tend to divide quickly and grow out of control. What is Cancer? This note covers the following topics: Telomeres, DNA Tumor Viruses, RNA Tumor Viruses, Oncogenes, Rb, Cell cycle, Growth hormone signal transduction, Apoptosis and Developmental signaling. Lecture 20: Cell-Cycle Regulation and the Genetics of Cancer Read chapter 15.1-6 (642-675) 2 The normal cell division The cell cycle has four phases: G 1, S G 2, and M. 3 Isolation of temperature-sensitive mutants in yeast •Mutants grow normally at permissive temperature •Mutants loses gene Part 2: Exploration of a basic understanding of cancer from a historical perspective. DREAM Challenges . Icahn School of Medicine at Mt Sinai . Lecture 6: The origin of autoimmune diseases (type 1- diabetes, thyroiditis) Lecture 7: Inflammation and fibrosis as a bistable system Lecture 8: Cancer and evolutionary trade-offs Part 3: Aging Lecture 9-11: Why and how we age, and the origin of age-related diseases Figure 1.1 Bathsheba at Her Bath, Rembrandt van Rijn, 1654 The dark shadow in the left breast may be a cancer. Cancer is one of the most common diseases in the developed world: 1 in 4 deaths are due to cancer 1 in 17 deaths are due to lung cancer Lung cancer is the most common cancer in men Breast cancer is the most common cancer in women There are over 100 different forms of cancer Cancer Radiation therapy is always a balance between destroying the cancer cells and minimizing damage to the normal cells. Cancer continued; three cancer types • Carcinomas; constitute 90% of cancers, are cancers of epithelial cells History of Oncogenes: Retroviral Oncogenes The damage to normal cells causes unwanted side effects. Introduction to Systems Biology of Cancer Lecture 1 Gustavo Stolovitzky IBM Research . and Cancer Biology Study Guide is designed to help radiation oncologists achieve this goal. • Any attempt to provide a comprehensive overview of cancer-related knowledge would be futile — therefore the next two lectures will focus on topics undergoing particularly rapid progress. Radiation therapy kills cancer cells that are dividing, but it also affects dividing cells of normal tissues. This experience utilizes a series of four short video clips from the NIH Supplement: Cell Biology and Cancer. specific cancer therapies. Although cancer is complex, and environmental and other nongenetic factors clearly play a role in many stages of the neoplastic process, the … Author(s): Dr. John G. Burr Molecular Biology of Cancer or Oncogenes Lecture Notes. The Molecular Biology of Cancer Delaney Sullivan dsull@stanford.edu Undergraduate Student, Stanford University April 11, 2015. Review •Central Dogma of Molecular Biology •Mendelian Genetics ... - Peyton Rous, Nobel Lecture, 1966. Part 3: Class Lecture Notes.